Post Date June, 18 2023
Endometriosis is a familiar gynecological disease and one of the most serious diseases. It is important to clarify the disease factors and pay attention to reasonable prevention.
The causes of endometriosis
1. Ectopic cultivation: During menstruation in women, endometrial glandular epithelium and stromal cells enter the pelvis through the fallopian tubes with retrograde flow of menstrual blood, and are planted in the ovaries and adjacent pelvic peritoneum, where they continue to grow and spread, forming pelvic endometriosis. The endometrium can also spread to distant areas through lymph nodes and veins, leading to ectopic implantation. Endometriosis can occur in organs far from the pelvic cavity, such as the lungs, limbs, skin, muscles, etc., which may be the result of endometrial dissemination through blood circulation and lymph nodes.
2. Genetic factors: Endometriosis has a certain degree of familial clustering, and the onset of certain patients may be related to genetics. The incidence risk of mothers and sisters of patients with endometriosis is 7 times that of those without family history.
3. Immune and inflammatory factors: Abnormal immune regulation plays an important role in the occurrence and development of endometriosis, manifested as weakened immune monitoring function and cytotoxic effects of immune killer cells, which cannot effectively clear the ectopic endometrium. Endometriosis is related to inflammation such as peritonitis, manifested as an increase in megaphagocytes, inflammatory cytokines, growth factors, and angiogenic substances in the peritoneal fluid, promoting the survival, proliferation, local fiber proliferation, and adhesion of ectopic endometrium.
4. Other factors: environmental factors may also increase the incidence rate of endometriosis, and dioxins found that women have an increased risk of endometriosis. Angiogenetic factors may also cause the occurrence of endometriosis, with an increase in vascular growth factors in the peritoneal fluid and an increase in pelvic microvascular growth, leading to endometriosis. In addition, the decrease in apoptosis of ectopic endometrial cells may also be related to the progression of the disease.
Hazards of endometriosis
1. Infertility: 40% -50% of infertility is related to endometriosis. Endometriosis can cause pelvic adhesions, rigidity or even obstruction of the fallopian tubes, leading to asynchronous retrograde movement of the fertilized egg with the endometrium, or obstructing the retrograde movement of the fertilized egg itself, resulting in infertility.
2. Lower abdomen and lumbosacral pain: Pain is one of the common symptoms, with obvious pain in the lower abdomen and lumbosacral region. It often starts 1-2 days before the onset of menstruation, and the menstrual period is severe, gradually reducing in the future.
