Post Date September, 25 2023
Androgenic alopecia usually occurs in Young adult with strong secretion of Sebaceous gland. Hair is closely related to hormones, with male hormones inhibiting hair growth while female hormones promoting hair growth. In particular, male hormones play a completely different role in various parts of the body, or in the occipital part of the head and the forehead.
The sensitivity of male hormones related to hair in a person's head varies depending on the location. The key to causing these phenomena lies in the receptor disk of hormones, which is the receptor body.
Hair loss is controlled by hair papilla cells, which are responsible for hair growth. Research on receptors has shown that hair cells on the top of the male head are more binding proteins to male hormone receptors than hair on the top of the female head.
The number of receptors in dermal papilla cells is determined by genetics. At the beginning, there were individual differences or the fact that hair loss was inherited in a family system. Not only that, whether hair will be bald or whether it is in the same person's head, there will be differences depending on the location, which is influenced by the number of male hormone receptors in the hair papilla. Male hormones promote hair loss due to the involvement of hair cells. Testosterone, a male hormone produced by the testes, circulates with the blood to the hair follicles and enters the cytoplasm through the cell membrane. There are 5 in the cytoplasm α- Reductase, which increases the effect of testosterone on DHT by a factor of five. The powerful DHT enters the nucleus and has an effect on the metabolic system. The production of ATP substances, particularly those with cellular energy effects, will be hindered as a result. When ATP, as a source of heat, cannot be produced and therefore cannot undergo protein synthesis in hair, hair mother cells lose vitality, begin keratinization, and finally become dormant hair. Hair that enters the resting period will lose its hair within about 3 months. In summary, DHT is the true culprit of male type hair loss, which can have a toxic effect on hair follicles, causing them to gradually shrink, shortening the hair growth cycle, and thus triggering the process of male type hair loss.
The cause of male baldness has only been discovered in recent years. Due to different genetic constitutions of individuals, testosterone secreted in certain body tissues (such as hair follicles on the scalp) can be reduced by 5a reductase (5 α- Dihydrotestosterone DHT is called hair follicle killer. The range of male baldness is in special areas, and due to the different resistance of hair follicles to male hormones, most of the bald areas are located above the forehead, head, and back headrest. The genes in these hair follicles are particularly different, and their resistance to DHT is very poor. Genetic genes begin to manifest after puberty, producing a large amount of 5a reductase in hair follicles that are prone to baldness. After puberty, men produce a large amount of male hormones, which are converted into DHT and have a strong destructive effect on these hair follicles. There are a large number of 5 in these hair follicles α- Reductase (5 α- Reduces) will convert male hormones to produce a large amount of metabolite dihydrotestosterone (DHT), and hair follicles will begin to shrink and degenerate, and hair loss will begin. The older you are, the more DHT accumulates, the more obvious baldness will become.
