What are the new treatments for prostate cancer? How effective is the targeted treatment of prostate cancer

Some research institutions have found new targets for the treatment of prostate cancer. This study shows that orphan nuclear receptor ROR γ It is very high in metastasis-resistant prostate cancer, and ROR γ Control the expression of androgen receptor AR. ROR obtained through theoretical simulation and design γ A small molecule inhibitor can effectively inhibit the expression level of AR gene and protein. Therefore, ROR gamma can be an important therapeutic target for prostate cancer, and the development of ROR gamma antagonists will become a new strategy for the treatment of prostate cancer.

In recent years, the treatment of advanced prostate cancer, especially metastatic castration resistant prostate cancer, has developed rapidly. The androgen receptor AR, one of the nuclear hormone receptor members, is the key therapeutic target of prostate cancer.

This study found that in addition to AR, nuclear audience ROR γ It also plays an important role in the progress of metastatic prostate cancer. ROR γ It is highly expressed in metastatic tumors, and the level of expression is closely related to the degree of tumor metastasis. The research team adopted the structure-based drug design method to obtain the ROR γ And XY011 and XY018. The latter two can inhibit the ROR γ， Effectively prevent the expression level of AR gene and protein, and inhibit the growth of tumor.

This study not only provides new anti-tumor targets, but also provides important lead compounds, providing an important way for the treatment of resistant prostate cancer. Before this research is officially promoted to clinical practice, we must first prevent our own cancer.

Be alert to prostate cancer when frequent and urgent urination occurs

Because the initial symptoms of prostatitis and prostate cancer are very similar, such as frequent urination, urgency of urination and difficulty in urination, many male patients confuse prostate cancer and prostatitis, and see a doctor after other symptoms

Therefore, in case of frequent urination, urgency and difficulty in urination, you must seek medical attention immediately to avoid serious illness caused by minor illness.

The symptoms of prostate cancer are firstly manifested as weak urination, slow urination, difficult urination, frequent urination, increased nocturia, and occasional hematuria; Secondly, with the increase of the tumor, there may be pressure phenomena such as difficulty in defecation, constipation, anal distension and discomfort. In addition, with the metastasis of the tumor, the most common is the bone and lymph of the patient, which may cause bone pain or fracture. Finally, with the development of the disease, anemia, malignant disease and renal failure may occur.