Post Date April, 15 2023
What are the drugs for treating sexual dysfunction? Traditional Chinese medicine experts have introduced us to the classification, including traditional Chinese medicine that has aphrodisiac effects or can treat sexual dysfunction. The commonly used methods include tonifying the kidney, promoting blood circulation and resolving stasis, clearing heat and detoxifying, etc. Among them, the method of tonifying the kidney is the most valued.
Among the drugs used to treat sexual dysfunction, the therapeutic mechanisms of commonly used Chinese medicines are as follows:
① Improve the immune function of the body. The immune function of the body includes two categories: cellular immunity and body immunity. The "quality" and "quantity" of T cells are important indicators of cellular immunity. "Warming kidney yang drugs or yang enhancing drugs such as Xianmao, Cuscuta chinensis, and Cynomorium songaricum can promote the formation of antibodies in advance. When these drugs are used primarily to treat kidney deficiency, they can exhibit lymphocyte transformation effects.".
② Improve endocrine regulation function. In most patients with deficiency syndrome, degeneration or atrophy of the endocrine glands can often be seen in the pathomorphology, and degenerative changes in varying degrees can be seen in the anterior pituitary, adrenal cortex, thyroid, testicle, or ovary. Other tissue cells can also undergo atrophy and degeneration, which is the material basis for organ and tissue dysfunction. In patients with severe deficiency syndrome, degeneration or atrophy of cells with special functions can be seen, replaced by fibrous connective tissue, resulting in dysfunction of the entire organ. The method of tonifying the kidney can regulate the functions of the hypothalamic pituitary adrenal cortex and thyroid system, and improve the excitability of the pituitary adrenal axis inhibited by exogenous hormones. Using kidney tonifying method to induce ovulation in the treatment of various gynecological diseases can achieve good results. The kidney tonifying formula can regulate the function of the hypothalamus pituitary ovarian axis.
Acanthopanax senticosus has an excitatory effect on the adrenal cortex system of rats and a promoting effect on gonadal function. Codonopsis pilosula can significantly increase the level of plasma corticosterone in mice. Rehmannia glutinosa can enhance the decreased adrenal cortical function. Pharmacological studies have found that kidney tonifying drugs such as Ziheche, Morinda officinalis, Polygonum multiflorum, Aconite, and Glycyrrhiza have adrenocortical hormone like effects.
Ginseng can stimulate the pituitary gland to secrete gonadotropins, accelerating the process of sexual maturation. Epimedium has androgen like effects. The ethanol extract of Fructus Cnidii has a stronger effect than Epimedium. Gekko gecko ethanol extract can prolong the estrous phase of normal female mice, induce estrous phase in ovariectomized mice, and have androgen like effects. Ziheche, Cordyceps sinensis, etc. have similar sex hormone like effects. Psoralea corylifolia has estrogen like effects, but is very weak. Ginseng may have gonadotropin like effects.
③ Improve bone marrow hematopoietic function. The treatment of chronic aplastic anemia mainly with the method of tonifying the kidney has significantly improved its efficacy. Kidney tonifying drugs such as deer antler, rehmannia glutinosa, polygonum multiflorum, cynomorium songaricum, psoralen, and morinda officinalis can proliferate red blood cells and hemoglobin, and increase the content of adenosine triphosphate in hemoglobin and the content of cyclic guanosine monophosphate in bone marrow cells. Rehmannia glutinosa, Cornus officinalis, Cistanche deserticola and Cibotium canis can increase platelet. Ginseng can increase red blood cells, white blood cells, and hemoglobin in rabbits, with large monocytes increasing more in white blood cells. Ginseng can alleviate radiation damage to the hematopoietic system.
④ Improve the body's material metabolism. Ginseng has inhibitory effects on normal blood sugar and hyperglycemia caused by injection of adrenaline and hypertonic glucose. Protein synthesis promoting factors can be extracted from ginseng roots, mainly containing ginsenosides. This substance can promote the biosynthesis of protein, DNA, and RNA, improve the activity of RNA polymerase, increase the synthesis rate of serum protein, increase the content of albumin and r-globulin, promote the division of bone marrow cells, and have an upward trend in red blood cells and white blood cells. Ginsenosides can promote animal growth and weight gain, which may be related to the promotion of protein and RNA synthesis. Many Fuzheng Guben drugs have regulatory effects on nucleic acid metabolism and cyclic nucleotide metabolism, such as Cynomorium songaricum, Herba Epimedii, and Cuscuta chinensis, which can increase the rate of DNA synthesis.
⑤ Enhance the ability to resist stress and adjust the balance of yin and yang. Many Chinese herbal medicines for strengthening yang can improve the adaptability of the body, enhance its nonspecific resistance to various harmful stimuli, and restore disordered functions to normal. Ginseng can restore the increase in red blood cells caused by cobalt nitrate to normal, and increase the decrease in red blood cells caused by phenylhydrazine, showing a two-way regulatory effect. "Shengdi, Xuanshen, Ophiopogon japonicus, Turtle shell, etc. have the effect of adjusting the nucleic acid synthesis rate of" yin deficiency "animals. When the nucleic acid synthesis rate is higher than normal, it can be reduced, and when the nucleic acid synthesis rate is lower than normal, it can be increased.". "Yang boosting drugs (such as aconite, cinnamon, cistanche deserticola, epimedium, etc.) used in experimental yang deficiency animals have an increasing effect on the decrease of nucleic acid content and succinate dehydrogenase activity in the liver and spleen, while a decreasing effect on the increase of glycogen in the liver.".
Polysaccharides are very abundant in plant based traditional Chinese medicine for promoting yang, such as ginseng, ophiopogon japonicus, schisandra chinensis, cordyceps sinensis, ligustrum lucidum, lotus seed, wolfberry fruit, atractylodes macrocephala, and other drugs. After being steamed, the total sugar content of Rehmannia glutinosa increased. The sugar content of prepared Polygonum multiflorum Thunb is higher than that of raw Polygonum multiflorum Thunb, thereby enhancing its tonifying effect. Traditional Chinese medicines with rich sugar content, such as polygonatum, polygonatum, cornus, wolfberry fruit, fructus quinquefolii, and asparagus, are steamed for a long time, sunned for a long time, or steamed with alcohol, which are beneficial to the transformation and exudation of sugar components. Chinese yam, polygonatum, polygonatum odoratum, jujube, cistanche deserticola, and schisandra chinensis all contain a large amount of mucus. Ziheche contains nitrogen-containing polysaccharides.
Cordyceps sinensis contains 25% to 32% crude protein; The animal aphrodisiac gecko contains a large amount of protein; In addition to polysaccharides, Ziheche also contains a variety of hormones.
Polygonum multiflorum contains 3.7% lecithin, which is the main component of nervous tissue, especially the brain and spinal cord, and is also an important constituent of blood cells and cell membranes. It can promote the regeneration and development of cells, which is related to the functions of Polygonum multiflorum such as tonifying the liver and kidney, hair, benefiting blood essence, and treating spermatorrhea. Epimedium contains icariin, acanthopanax senticosus contains acanthopanax polysaccharides and acanthopanax senticosus glycosides, which are closely related to the tonifying and yang boosting effects of drugs.
⑥ Trace elements have many important physiological functions (such as those related to sexual function) and biological effects, and play an extremely important role in human life activities and metabolic processes. Trace elements are also very abundant in traditional Chinese medicine for strengthening yang, such as Acanthopanax senticosus and Astragalus, which have high levels of zinc, manganese, and selenium. The content of zinc and manganese in tonifying drugs, including yang strengthening drugs, tends to be higher than that of qi regulating drugs. Mineral aphrodisiacs such as magnetite and actinolite contain a variety of trace elements.
