Sexual Health
How does Polycystic ovary syndrome take contraceptives? How to treat Polycystic ovary syndrome with drugs
Post Date July, 13 2023
Oral contraceptives containing a combination of estrogen and Progestogen will increase the level of Sex hormone-binding globulin (SHBG), thereby reducing the level of free testosterone. The levels of Luteinizing hormone (LH) and follicle hormone (FSH) were also inhibited. This restores endometrial circulation, exposure to estrogen and pregnancy hormones, restores menstruation, and reduces the number of problems. However, the use of oral contraceptives may increase the risk of thrombosis and metabolic abnormalities.
How does oral contraception treat polycystic ovary syndrome?
1. Reduce Gonadotropin-releasing hormone
Oral contraceptives can reduce the secretion of pituitary luteinizing hormone and Follicle-stimulating hormone by reducing the amount of Gonadotropin-releasing hormone. All oral contraceptives can reduce the production of ovarian androgens. By inhibiting the secretion of Gonadotropin and the development of the third follicle, the ovarian secretion of testosterone and Androstenedione is reduced. All oral contraceptives increase Sex hormone-binding globulin, thereby reducing free testosterone. There is evidence to suggest that high-dose contraceptives may inhibit reductase activity. Oral contraceptives can also reduce the production of adrenal androgens, especially Dehydroepiandrosterone sulfate.
2. Increase Sex hormone-binding globulin
Different contraceptive preparations have different effects on ovarian androgen production and Sex hormone-binding globulin. However, it can reduce testosterone levels. The level of free testosterone obtained by oral contraceptives was not related to the increase of Sex hormone-binding globulin level. Preparations with Sex hormone-binding globulin levels also increase testosterone levels. That is to say, the decrease of free testosterone level in all oral contraceptives is the same. Although some of these preparations increase more Sex hormone-binding globulin levels than other preparations, the overall testosterone level increases with the increase, and this effect is offset. The restoration of normal Menstrual cycle can prevent endometrial hyperplasia related to anovulation. Oral contraceptives can also improve acne and multiple illnesses.
What drugs are there for Polycystic ovary syndrome?
Drugs for polycystic ovary syndrome also include ethinylestradiol. Acetylestradiol reduces the secretion of pituitary luteinizing hormone and Follicle-stimulating hormone by reducing the amount of Gonadotropin-releasing hormone. Acetylestradiol is used in combination with any form of progesterone. The restoration of normal Menstrual cycle can prevent endometrial hyperplasia associated with anovulation. Improved androgen effects can be observed in 60-100% of women, but typically require at least 6-12 months of use. Pregnancy test was conducted before treatment. If the patient has no menstruation for 3 months, use Depot medroxyprogesterone acetate to induce withdrawal bleeding for 10 days, and then start the treatment of oral contraceptives. Common ethinylestradiol drugs include medroxyprogesterone, which has no effect on the production of androgens. Progestogen can prevent the proliferation of endometrial cells and make them fall off after withdrawal.
