Post Date May, 19 2023
The emergence of endometriosis is particularly troublesome for many women and a serious gynecological disease. We must pay attention to its pathogenic factors and carry out reasonable prevention in many aspects.
The causes of endometriosis
1. Ectopic cultivation: During menstruation in women, endometrial glandular epithelium and stromal cells enter the pelvis through the fallopian tubes with retrograde flow of menstrual blood, and are planted in the ovaries and adjacent pelvic peritoneum, where they continue to grow and spread, forming pelvic endometriosis. The endometrium can also spread far through lymph nodes and veins, leading to ectopic cultivation. In clinical practice, endometriosis may occur in organs far from the pelvis, such as the lungs, skin of limbs, muscles, etc., which may be the result of endometrial transmission through blood circulation and lymph nodes.
2. Genetic factors: Endometriosis has a certain degree of familial clustering, and the onset of some patients may be related to genetics. The risk of mother and sisters of endometriosis patients is 7 times higher than that without family history.
3. Immune and inflammatory factors: Abnormal immune regulation plays an important role in the occurrence and development of endometriosis, with weakened immune monitoring function and cytotoxicity of immune killing cells, making it difficult to effectively eliminate ectopic endometrium. Endometriosis is related to inflammation such as peritonitis, manifested as an increase in megaphagocytes, inflammatory cytokines, growth factors, and angiogenic substances in the peritoneal fluid, promoting the survival, proliferation, local fiber proliferation, and adhesion of ectopic endometrium.
4. Other factors: environmental factors may also increase the incidence rate of endometriosis, and dioxins found that women have an increased risk of endometriosis. Angiogenetic factors may also cause the occurrence of endometriosis, with an increase in vascular growth factors in the peritoneal fluid and an increase in pelvic microvascular growth, leading to endometriosis. In addition, the decrease in apoptosis of ectopic endometrial cells may also be related to the progression of the disease.
The hazards of endometriosis
1. Infertility: 40% -50% of infertility is related to endometriosis. Endometriosis can cause pelvic adhesions, hard fallopian tubes, or even blockage, causing the gestational egg to retrograde out of sync with the endometrium, or causing retrograde infertility of the gestational egg itself.
2. Lower abdominal and lumbosacral pain: Pain is one of the common symptoms, with obvious lower abdominal and lumbosacral pain that starts 1-2 days before menstruation, becomes severe physiologically, and gradually decreases thereafter.
