Choriocarcinoma is a disease that we should pay attention to. It is also a serious gynecological disease, especially after illness, patients will also have symptoms, and must be checked and diagnosed immediately.
What is choriocarcinoma?
Choriocarcinoma is a Gestational trophoblastic disease, which is a trophoblastic tumor secondary to normal or abnormal pregnancy, and belongs to malignant tumor. There are 50% choriocarcinoma after Molar pregnancy, 25% choriocarcinoma after abortion, and 10% choriocarcinoma after term delivery or Ectopic pregnancy. This disease often occurs in women of childbearing age, and occasionally in unmarried women, it is called primary choriocarcinoma.
Symptoms of Choriocarcinoma
1. Vaginal bleeding: bleeding after raisin curettage, abortion or term delivery, or after Ectopic pregnancy. Sometimes there is no uncertain amount of bleeding, and vaginal bleeding after temporary cessation of normal menstruation.
2. Abdominal mass: The uterus is unevenly enlarged, and patients often feel a mass in the lower abdomen.
3. Symptoms similar to pregnancy: mainly refer to symptoms such as enlarged breasts, darker nipple and areola colors, and softer vagina.
4. Local bleeding: When a disease metastasizes, the common feature of each metastatic site is local bleeding. The most common is lung metastasis, which may lead to hemoptysis, followed by Parametrium and vaginal metastasis, and then brain metastasis
5. Complicated pregnancy: when swan's choriocarcinoma complicates pregnancy, not only massive uterine bleeding occurs during pregnancy, but also it is often misdiagnosed as Placenta praevia, and bleeding during delivery is also very serious, often misdiagnosed as placental abruption.
Choriocarcinoma examination
1. Determination of HCG in blood or urine (Human chorionic gonadotropin): positive after the titre rises or HCG in blood or urine is negative.
2. X-ray examination: There are spherical shadows in the lungs, distributed in both lung fields, and sometimes only one metastatic lesion. Or several nodules can fuse into cotton balls, forming a massive lesion.
3. Uterine iodine oil imaging or pelvic imaging: muscle layer erosion.
4. Pelvic ultrasound: Enlargement of the uterine body, disappearance or interruption of endometrial echoes, honeycomb like hypoechoic masses appearing in or near the uterus, and luteinized cysts visible in the ovaries
5. Biopsy tissue examination: Pathological examination of the primary lesion of the uterus can ultimately confirm the diagnosis.
6. Pathological diagnosis: In the Myometrium or other resected organs, a large number of necrotic tissues and clots can be seen, and a large number of active trophoblasts can be seen around them, without villus structure.