Post Date July, 18 2023
In the era of Genital wart prevalence, it is necessary for us to understand the disease inspection items. Why do experts say that? This is because the harm of Genital wart is quite great, which will seriously damage everyone's body and mind. Know how to do the inspection, find out whether it is infected as soon as possible, and treat it as soon as possible.
1. Acetic acid white test: Apply 3-5% acetic acid externally to warts for 2-5 minutes. The affected area will become white, slightly raised, and anal damage may take 15 minutes. The principle of this test is the result of protein and acid coagulation and whitening. The Keratin produced by HpV infected cells is different from normal uninfected epithelial cells. Only the former can be decolorized by acetic acid. The sensitivity of acetic acid white test for detecting HpV is high, and it is better than conventional detection for observing histological changes. However, in cases of epithelial thickening or traumatic abrasions, occasional false positives and signs of false positive whitening may appear, which seems unclear and irregular. The CDC in the United States suggests that the acetic acid white test is not a special test, and false positives are more common.
2、 Immunohistological examination: the commonly used peroxidase anti peroxidase method (peroxidase) pAp), in order to prove that there is viral antigen in the wart damage, the Viral protein in the condyloma is displayed. When HpV protein is positive, the superficial epithelial cells of Genital wart appear light red weak positive reaction.
3. Histochemical examination: Take a small amount of damaged tissue and make a smear, and stain it with special anti human papillomavirus antibodies. If there is a viral antigen in the lesion, the antigen antibody binds. In this method, the nucleus can be stained red with anti peroxidase (pAp). This method has strong specificity, fast speed, and is helpful for diagnosis.
4、 Pathological examination: Mainly characterized by incomplete keratinization, high thickness of the spinous layer, papillomatous hyperplasia, thickening and elongation of the epidermal process, and the degree of hyperplasia may be pseudoepithelial tumor like. Spine cells and basal cells undergo a considerable amount of nuclear division and carcinogenesis. But the cells are arranged in a regular manner, and the boundary between proliferative epithelium and dermis is is clear. It is characterized by the formation of obvious vacuoles in the cells on the Stratum granulosum and prickle layer. This type of vacuolar cell is larger than normal, with light cytoplasmic staining, a large and round center, and a deep basophilic nucleus. Usually skin edema, Telangiectasia and surrounding dense chronic inflammatory infiltration. Bushke loewenstein giant Genital wart, the epidermis is extremely downward growth, rather than the underlying tissue, easy to mix with squamous cells, so multiple biopsies are required. If there is a tendency for slow development, so-called verrucous cancer is a low-grade malignant transformation process.
